Methods: Data between 1 January 2006 and 31 December 2014 from patients aged 6-17 years in the Truven Health Analytics MarketScan database were used to generate two cohorts of patients: (1) atomoxetine users and (2) stimulant (methylphenidates or amphetamines) users. In addition, the findings of this study show that for some medications and disease indications, an observational cohort study using existing data may offer a viable alternative to prospective pregnancy registries in meeting the objectives of a postmarketing pregnancy safety surveillance. There is a need for alternative and or complementary methodological approaches to evaluating the safety of medications during pregnancy. AU - Hollenbeak, Christopher S. PY - 2019. Background: Our study demonstrates the power of EHRs for clinical description of CF and the benefits of using a genetics-informed weighing scheme in construction of a phenotype risk score. Data S1: Appendix S1: Migraine case finding algorithm in the Marketscan database. International Journal of Medical Informatics. Y1 - 2019. GReX of CFTR was associated with EHR phenotypes consistent with CF. As shown in Table 2, the majority of pregnant women in the claims analysis were aged 30 to 39 (59.3% of the sumatriptan‐exposed cohort, 62.2% of the naratriptan‐exposed cohort, and 63.9% of the sumatriptan/naproxen sodium). In summary, endophenotype‐based network medicine methodologies will promote AD therapeutic development that will optimize the usefulness of available data and support deep phenotyping of the patient heterogeneity for personalized medicine in AD. There are several potential methodological challenges associated with the use of administrative claims databases in investigating outcomes of drug exposure during pregnancy that may benefit from further exploration. The consistency observed between the key findings of the retrospective claims analysis and the registry regarding pregnancy outcomes in the setting of sumatriptan exposure supports the feasibility of retrospective observational study approaches in evaluating post‐approval safety of triptan exposure in pregnancy. MarketScan data also contain diagnoses which can be used to determine the influence of clinical, demographic, and provider characteristics upon prescribing patterns. Specifically, we discuss six main endophenotype hypotheses in AD: amyloidosis, tauopathy, neuroinflammation, mitochondrial dysfunction, vascular dysfunction, and lysosomal dysfunction. MarketScan Ⓡ MarketScan Ⓡ Inpatient View; Diagnosis/Procedure Query; Link View Query; MarketScan Ⓡ Outpatient View; Diagnosis/Procedure Query; Admin; User List; User Activity Report; Expiration Report To draw meaningful inferences from such studies, it is essential to fully understand the characteristics of the underlying population and potential biases in EMRs. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Retrospective claims analysis cohort identification flowchart [Colour figure can be viewed at, orcid.org/http://orcid.org/0000-0002-0001-1311, I have read and accept the Wiley Online Library Terms and Conditions of Use, Pregnancy and protection: the ethics of limiting a pregnant woman's participation in clinical trials, U.S. Department of Health and Human Services, Evaluating the safety of medication exposures during pregnancy: a case study of study designs and data sources in multiple sclerosis, The safety of medications in pregnant women: an opportunity to use database studies, Healthcare databases in Europe for studying medicine use and safety during pregnancy, Promise and pitfalls of administrative data in evaluating pregnancy outcomes, Final results from the 16‐year sumatriptan, naratriptan, and treximet pregnancy registry, Development of an algorithm to identify pregnancy episodes in an integrated health care delivery system, Surveillance of medication use during pregnancy in the Mini‐Sentinel Program, Assessing the safety of influenza immunization during pregnancy: the Vaccine Safety Datalink, ICD‐9 and CDC/BPA codes for the forty‐seven reported birth defects, Observational study to assess maternal and foetal outcomes following exposure to albiglutide during pregnancy, Food and Drug Administration. Development and Evaluation of MADDIE: Method to Acquire Delivery Date Information from Electronic Health Records. Main Outcomes and Measures Colorectal cancer accounted for more than half of all GI cancers and was the leading cause of GI-related mortality (52,394 deaths). MarketScan® Commercial Claims and Encounters. IBM® MarketScan® Research Databases provide one of the longest-running and largest collections of proprietary de-identified claims data for privately and publicly insured people in the US. In the original validation study of the algorithm used to assign gestational age for non‐livebirth outcomes in the present claims analysis, about 20% of pregnancies resulting in non‐livebirth outcomes had none of the procedures that were used in the algorithm.11 However, any misclassification arising from imperfect ascertainment of gestational age is likely nondifferential across the 3 exposure cohorts and poses minimal bias to our study findings. Objective: To study the trends on JMG using Truven Health MarketScan commercial claims database. Thus, adverse outcomes that are more likely to occur earlier during the course of the pregnancy are likely to be underestimated in the registry relative to the claims analysis. These results confirm broad agreement between the database analysis and the registry regarding the safety of triptans during pregnancy. The authors declare no conflict of interest. Mothers and infants were linked for completed pregnancies resulting in livebirth deliveries using their insurance ID, information on delivery‐related claims date, infant birth year, and infants' first enrollment date. Ten-year trend … Truven MarketScan is the most recent database to be installed on CTSC servers. Women aged 15-49 years with claims for HS and LS procedures were identified from two MarketScan databases, one consisting of commercial claims and the other Medicaid claims, during the time period of January 1, 2003 to December 31, 2012 and January 1, 2006 to December 31, 2011, respectively. Mean adjusted costs were $13,863 for cetuximab administrations with an IR requiring ER visit or hospitalization and $6280 for those with an IR requiring outpatient treatment, compared with $4555 for those without an IR. The Truven Health MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental and Coordination of Benefits Database (Truven Health Analytics Inc, Ann Arbor, MI) included data from January 1, 2007, to September 30, 2015. The MarketScan® Commercial Claims and Encounters Data (CCAE) is produced … February 1, 2015, using MarketScan data for the Real World: the distribution of major diseases! 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Market Scan solutions help companies optimize their competitiveness and profitability, as well as hundreds of quality... 670 exposed pregnancies were truven marketscan database in comparison with 670 exposed pregnancies in the United States total...